ea0090p282 | Adrenal and Cardiovascular Endocrinology | ECE2023
Feely Sarah
, Donlon Padraig
, Mullen Nathan
, Sorushanova Anna
, P Finn David
, Hernan Brendan
, Carroll Oliver
, Owens Peter
, Pandit Abhay
, Hantel Constanze
, C Dennedy Michael
Adrenocortical carcinoma (ACC) is a rare malignancy associated with a poor prognosis (1). Current treatments are limited with surgical resection the only option for a complete cure (2). The development of translational therapies is limited by pre-clinical disease models. Three-dimensional (3D) cell culture models can accurately reflect the tumour micro-environment but are lacking in ACC (3). In the current study, we developed and characterised novel 3D models of MUC-1, HAC15 a...